Alleviation of cisplatin-induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase-3 activity.

Fatemeh Taghizadeh Seyed Jalal Hosseinimehr Mehryar Zargari Abbasali Karimpour Malekshah Mansooreh Mirzaei Fereshteh Beigom Talebpour Amiri

Published in: Pharmacology research & perspectives (2022)

In conclusion, GLZ with its antioxidant, anti-inflammatory, and anti-apoptotic activities, can be suggested as a promising drug in the treatment of CP-induced hepatotoxicity.

Keyphrases

anti inflammatory
drug induced
oxidative stress
diabetic rats
cell death
induced apoptosis
high glucose
dna damage
ischemia reperfusion injury
emergency department
signaling pathway