Injectable hydrogel-mediated combination of hyperthermia ablation and photo-enhanced chemotherapy in the NIR-II window for tumor eradication.
Gang WangNa ZhangZiyang CaoZhenghai ZhangZhongming ZhuGengyun SunLiangjie JinXian-Zhu YangPublished in: Biomaterials science (2021)
Local administration of therapeutic agents with long-term retention capabilities efficiently avoids nonspecific distribution in normal organs with an increased drug concentration in pathological tissue. Herein, we developed an injectable and degradable alginate-calcium (Ca2+) hydrogel for the local administration of corn-like Au/Ag nanorods (NRs) and doxorubicin hydrochloride (DOX·HCl). The immobilized Au/Ag NRs with strong absorbance in the near-infrared II (NIR-II) window efficiently ablated the majority of tumor cells after 1064 nm laser irradiation and triggered the release of DOX to kill residual tumor cells. As a result, injectable hydrogel-mediated NIR-II photothermal therapy (PTT) and chemotherapy efficiently inhibited tumor growth, resulting in the complete eradication of tumors in most of the treated mice. Furthermore, owing to the confinement of the Au/Ag NRs and DOX·HCl within the hydrogel, such treatment exhibited excellent biocompatibility.
Keyphrases
- tissue engineering
- hyaluronic acid
- drug delivery
- photodynamic therapy
- sensitive detection
- drug release
- reduced graphene oxide
- wound healing
- quantum dots
- visible light
- fluorescence imaging
- helicobacter pylori infection
- fluorescent probe
- locally advanced
- highly efficient
- gold nanoparticles
- squamous cell carcinoma
- emergency department
- radiation therapy
- type diabetes
- radiation induced
- skeletal muscle
- insulin resistance
- protein kinase
- high resolution
- adverse drug
- rectal cancer
- capillary electrophoresis