Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis.

Taiqiu ChenYan PengWenjun HuHuihong ShiPengfei LiYichen QueJincheng QiuXianjian QiuBo GaoHang ZhouYanbo ChenYuanxin ZhuShaoguang LiAnjing LiangWenjie GaoDongsheng Huang

Published in: Stem cell research & therapy (2022)

Collectively, our study reveals that irisin can enhance chondrogenic differentiation of hMSCs via the Rap1/PI3K/AKT pathway, suggesting that irisin possesses prospects in cartilage regeneration.

Keyphrases

mesenchymal stem cells
pi k akt
signaling pathway
umbilical cord
cell proliferation
endothelial cells
cell cycle arrest
stem cells
bone marrow
cell therapy
extracellular matrix
induced pluripotent stem cells
current status