A divergent and concise total synthesis of (-)-lycoposerramine R and (+)-lycopladine A.
Sheng ChenJinming WangFayang G QiuPublished in: Chemical communications (Cambridge, England) (2018)
A concise, asymmetric and divergent synthesis of lycoposerramine R and lycopladine A is presented. The synthesis features the palladium-catalyzed cycloalkenylation of a silyl enol ether for assembling the 5/6-hydrindane system and generating a quaternary carbon center in one step.
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