Application of PLGA nano/microparticle delivery systems for immunomodulation and prevention of allotransplant rejection.

Sanaz Keshavarz ShahbazFarshad ForoughiEhsan SoltaninezhadTannaz JamialahmadiPeter E Penson Amir Hossein Sahebkar

Published in: Expert opinion on drug delivery (2020)

Biomaterial-based approaches using micro- and nanoparticles such as poly (lactic-co-glycolic acid) (PLGA) can be used to achieve controlled release of drugs. This approach decreases the required effective dose of drugs and enables local delivery of these agents to specific tissues and cells, whilst decreasing systemic effects.

Keyphrases

drug delivery
induced apoptosis
drug release

cell cycle arrest
gene expression

bone regeneration
oxidative stress

signaling pathway
walled carbon nanotubes