Inhibition of DNMT1 attenuates experimental food allergy.

Linjing LiWenjing PangLingzhi XuYuanyi ZhangHanqing ZhangLiming ZhuYuyi LiHuapeng LinLihua MoYu LiuLei WangPingchang Yang

Published in: Molecular immunology (2024)

The elevated quantity of DNMT1 in intestinal Breg cells compromises the expression of IL-35 and affects the immune regulatory functions, which facilitates the development of FA. The immune regulatory functions of intestinal Breg cells are restored and experimental FA is attenuated by inhibiting DNMT1.

Keyphrases

induced apoptosis
dna methylation
cell cycle arrest
transcription factor
endoplasmic reticulum stress
oxidative stress
cell proliferation
binding protein