IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes.
Elham MemarianRalph HeijmansRoderick C SliekerAdriana SierraOlga GornikJoline W J BeulensMaja HanicPetra EldersJulio PascualEric J G SijbrandsGordan LaucViktoria DotzClara BarriosLeendert M 't HartManfred WuhrerMandy van HoekPublished in: Diabetes/metabolism research and reviews (2023)
We showed that IgG N-glycosylation, particularly galactosylation and to a lesser extent sialylation, is associated with a higher prevalence and future development of macro- and microvascular complications of diabetes. These findings indicate the predictive potential of IgG N-glycosylation in diabetes complications and should be analysed further in additional large cohorts to obtain the power to solidify these conclusions.