TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis.

Jimin JeonHyun-Jin NohHyemi LeeHan-Hee ParkYu-Jin HaSeok Hee ParkHaeseung LeeSeok-Jung KimHo Chul KangSeong-Il EyunSiyoung Yang You-Sun Kim

Published in: Annals of the rheumatic diseases (2020)

TRIM24-RIP3 axis perturbation promotes OA chronicity by activating RIP3 kinase, suggesting that the therapeutic manipulation of this pathway could provide new avenues for treating OA.

Keyphrases

knee osteoarthritis
rheumatoid arthritis
signaling pathway
tyrosine kinase