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Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles.

Shilah A BonnettAlyssa B RosenbloomGiang T OngMark ConnerAric B E RiningerDaniel J NewhouseFelicia NewChi Q PhanSaskia IlcisinHiromi SatoJohn S LyssandGary GeissJoseph M Beechem
Published in: Cancer research communications (2023)
We describe ultra high-plex spatial proteogenomics; profiling whole transcriptome and high-plex proteomics on a single FFPE tissue section with spatial resolution. Investigation of gcGBM versus GBM revealed distinct protein and RNA expression profiles.
Keyphrases
  • giant cell
  • single cell
  • high resolution
  • gene expression
  • mass spectrometry
  • protein protein
  • rna seq
  • amino acid
  • genome wide
  • small molecule