A Novel Locus on 6p21.2 for Cancer Treatment-Induced Cardiac Dysfunction Among Childhood Cancer Survivors.
Yadav SapkotaMatthew J EhrhardtNa QinZhaoming WangQi LiuWeiyu QiuKyla SheltonYing ShaoEmily PlylerHeather L MulderJohn EastonJ Robert MichaelPaul W BurridgeXuexia WangCarmen L WilsonJohn L JefferiesEric J ChowKevin C OeffingerLindsay M MortonChunliang LiJun J YangJinghui ZhangSmita BhatiaDaniel A MulrooneyMelissa M HudsonLeslie L RobisonGregory T ArmstrongYutaka YasuiPublished in: Journal of the National Cancer Institute (2022)
Leveraging the 2 largest cohorts of childhood cancer survivors in North America and survivor-specific polygenomic functional data, we identified a novel risk locus for CCD, which showed specificity with doxorubicin-induced cardiac dysfunction and highlighted dysregulation of KCNK17 as the likely molecular mechanism underlying this genetic association.