Scalarane Sesterterpenoids with Antibacterial and Anti-Proliferative Activities from the Mushroom Neonothopanus nambi .
Awat WisetsaiRatsami LekphromSureeporn Bua-ArtThanapat SuebrasriSophon BoonlueSarawut TontaphaVittaya AmornkitbamrungThanaset SenawongFlorian T SchevenelsPublished in: Molecules (Basel, Switzerland) (2021)
Seven undescribed scalarane sesterterpenoids, nambiscalaranes B-H ( 1 - 7 ), together with two known compounds, nambiscalarane ( 8 ) and aurisin A ( 9 ) were isolated from the cultured mycelium of the luminescent mushroom Neonothopanus nambi . Their structures were elucidated by thorough analysis of their 1D and 2D NMR spectroscopic data. The absolute configurations of 1 - 8 were determined by electronic circular dichroism (ECD) calculations and optical rotation measurements. The isolated sesterterpenoids were evaluated against A549, HT29, HeLa, and HCT-116 cancer cell lines, and against five bacterial strains. Compounds 3 , 5 , and 7 showed strong cytotoxicity against HCT-116 cell line, with IC 50 values ranging from 13.41 to 16.53 µM, and showed no cytotoxicity towards Vero cells. Moreover, compound 8 inhibited the growth of Bacillus subtilis with a MIC value of 8 µg/mL, which was equivalent to the MIC value of the standard kanamycin.
Keyphrases
- cell cycle arrest
- bacillus subtilis
- cell death
- high resolution
- pi k akt
- papillary thyroid
- induced apoptosis
- molecular docking
- magnetic resonance
- escherichia coli
- density functional theory
- molecular dynamics
- electronic health record
- molecular dynamics simulations
- quantum dots
- big data
- sensitive detection
- silver nanoparticles
- cell proliferation
- machine learning
- oxidative stress
- mass spectrometry
- squamous cell carcinoma
- lymph node metastasis
- metal organic framework
- endoplasmic reticulum stress