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Glyphosate Use and Mosaic Loss of Chromosome Y among Male Farmers in the Agricultural Health Study.

Vicky C ChangWeiyin ZhouSonja I BerndtGabriella AndreottiMeredith YeagerChristine G ParksDale P SandlerNathaniel RothmanLaura E Beane FreemanMitchell J MachielaJonathan N Hofmann
Published in: Environmental health perspectives (2023)
High lifetime glyphosate use could be associated with mLOY affecting a larger fraction of cells, suggesting glyphosate could confer genotoxic or selective effects relevant for clonal expansion. As the first study to investigate this association, our findings contribute novel evidence regarding the carcinogenic potential of glyphosate and require replication in future studies. https://doi.org/10.1289/EHP12834.
Keyphrases
  • public health
  • mental health
  • induced apoptosis
  • dna methylation
  • gene expression
  • cell proliferation
  • oxidative stress
  • endoplasmic reticulum stress
  • social media
  • case control