Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis.

Ravi K KomaravoluPadmaja Mehta-D'souzaTaylor ConnerMadeline AllenJessica LumryAlbert BatushanskyNathan P PezantCourtney G MontgomeryTimothy M Griffin

Published in: Osteoarthritis and cartilage (2024)

Acute βAR activation altered synovial-IFP transcription in a sex and injury-dependent manner, suggesting that women with PTOA may be more sensitive than men to treatments targeting sympathetic neural signaling pathways.

Keyphrases

signaling pathway
liver failure
rheumatoid arthritis
knee osteoarthritis
drug induced
middle aged
epithelial mesenchymal transition
intensive care unit
aortic dissection
hepatitis b virus
mechanical ventilation