Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments.

Jonatan Dewulf Ivanna HrynchakSarah GeudensIsabel PintelonChristel VangestelJosé Sereno Peter A van Dam Antero José Abrunhosa Filipe Elvas Tim Van den Wyngaert

Published in: Pharmaceutics (2022)

Cu]Cu-NOTA-denos-Fab, that allows for fast tumor imaging with improved imaging contrast when compared with its antibody counterpart, showing promise as a potential PET RANKL imaging tool for future clinical applications.

Keyphrases

pet imaging
high resolution
magnetic resonance
positron emission tomography
computed tomography
magnetic resonance imaging
risk assessment
immune response
pet ct
machine learning
mass spectrometry
fluorescence imaging
big data
bone loss
human health
photodynamic therapy