Combination of Polymeric Micelle Formulation of TGFβ Receptor Inhibitors and Paclitaxel Produce Consistent Response Across Different Mouse Models of TNBC.

Natasha VinodDuhyeong HwangSloane Christian FussellTyler Cannon OwensOlaoluwa Christopher TofadeSage CoplingJacob D RamseyPatrick D RädlerHannah M AtkinsEric E LivingstonJ Ashley EzzellMarina Sokolsky- PapkovHong YuanCharles M PerouAlexander V Kabanov

Published in: bioRxiv : the preprint server for biology (2023)

Paclitaxel is a widely used chemotherapy in breast cancer. However, response to single-agent chemotherapy is short-lived in a metastatic setting. This study shows the broad applicability of the therapeutic combination of TGFβ inhibitors with Paclitaxel across different TNBC subtypes.

Keyphrases

chemotherapy induced
drug delivery
transforming growth factor
locally advanced
mouse model
squamous cell carcinoma
small cell lung cancer
radiation therapy
drug release
signaling pathway