Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the Gαi3-PKA-CREB-YAP axis.

Siyuan YinRu SongJiaxu MaChunyan LiuZhenjie WuGuoqi CaoJian LiuGuang ZhangHuayu ZhangRui SunAoyu ChenYi-Bing Wang

Published in: Cell communication and signaling : CCS (2022)

Based on these data, we report, for the first time, that changes in the total RAMP1 levels during wound healing and RAMP1 overexpression alone can promote MSF proliferation via the Gαi3-PKA-CREB-YAP axis, a finding critical for understanding RAMP1 function, suggesting that this pathway is an attractive and accurate nerve target for skin wound treatment. Video Abstract.

Keyphrases

wound healing
signaling pathway
cell proliferation
binding protein
soft tissue
big data
transcription factor
amino acid
data analysis
smoking cessation