Genome- and epigenome-wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk.

Robert F HillaryDanni A GaddDaniel L McCartneyLiu ShiArchie CampbellRosie M WalkerCraig W RitchieIan J DearyKathryn L EvansAlejo J Nevado-HolgadoCaroline HaywardDavid J PorteousAndrew M McIntoshSimon LovestoneMatthew R RobinsonRiccardo E Marioni

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2022)

Our data inform the regulation of biomarker levels and their relationships with AD.

Keyphrases

dna methylation
cognitive decline
electronic health record
genome wide
gene expression
machine learning
binding protein
artificial intelligence
mild cognitive impairment