Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2.

Yu RenYun-Fei WangJing ZhangQi-Xue WangLei HanMei MeiChun-Sheng Kang

Published in: Clinical epigenetics (2019)

Our findings suggest of a potential new strategy to discover the lead compound for targeted lincRNA therapy and potentially pave the way for exploiting ADQ as a scaffold for more effective small molecule drugs.

Keyphrases

small molecule
cancer therapy
tissue engineering
long non coding rna
drug delivery
stem cells
long noncoding rna
replacement therapy
chemotherapy induced