Efficacy and safety of ketoconazole combined with calmodulin inhibitor in solid organ transplantation: A systematic review and meta-analysis.

Ting XueTing YangChaoyang ChenSongtao WuMin LiLingyun MaYing ZhouYi Min Cui

Published in: Journal of clinical pharmacy and therapeutics (2019)

The co-administration of ketoconazole and CNIs can significantly reduce the dose of CNIs. This combination may be safely used as a CNI-sparing agent from the time of solid organ transplantation with low-dose ketoconazole, based on the findings of this review.

Keyphrases

low dose
cell therapy
high dose
robot assisted
protein kinase
bone marrow