Menin Maintains Cholesterol Content in Colorectal Cancer via Repression of LXR-Mediated Transcription.
Thomas E NyulKeely BeyriesTaylor HojnackiRebecca GlynnKayla E PauloskyAnitej GedelaAriana MajerLily AltmanKole H BuckleyZijie FengKunfeng SunZhicheng PengJohn W TobiasXianxin HuaBryson W KatonaPublished in: Cancers (2023)
in the colonic epithelium and CRC. Menin inhibition conversely upregulates LXR-target genes and reduces total cellular cholesterol, demonstrating that menin inhibition may be an important mechanism for targeting cholesterol-dependent pathways in colorectal carcinogenesis.