Efficacy and Safety of Direct Oral Anticoagulants for Acute Treatment of Venous Thromboembolism in Older Adults: A Network Meta-Analysis of Randomised Controlled Trials.

Renato Luís PessôaVitor Germano KesslerGabriel Goerck BeckerGabriel Moretti GarciaPedro Victor Duarte AraldiPedro Verza Aver

Published in: Vascular and endovascular surgery (2024)

Apixaban emerges as a favourable choice for acute VTE treatment in the elderly, displaying reduced bleeding risk compared to other treatments while maintaining comparable efficacy. Future studies should explore diverse anticoagulants efficacy and safety in older populations. Additionally, clinical prediction models tailored to geriatric cohorts are crucial for guiding treatment duration decisions.

Keyphrases

venous thromboembolism
direct oral anticoagulants
atrial fibrillation
liver failure
physical activity
respiratory failure
middle aged
drug induced
aortic dissection
community dwelling
hepatitis b virus
extracorporeal membrane oxygenation
case control
breast cancer risk