HIV integration and the establishment of latency in CCL19-treated resting CD4(+) T cells require activation of NF-κB.
Suha SalehHao K LuVanessa EvansDavid HarissonJingling ZhouAnthony JaworowskiGeorgina SallmannKarey Y CheongTalia M MotaSurekha TennakoonThomas A AngelovichJenny AndersonAndrew HarmanAnthony CunninghamLachlan GrayMelissa ChurchillJohnson MakHeidi DrummerDimitrios N VatakisSharon R LewinPaul U CameronPublished in: Retrovirology (2016)
HIV integration in CCL19-treated resting CD4(+) T cells depends on NF-κB signalling and increases the stability of HIV integrase, which allow subsequent integration and establishment of latency. These findings have implications for strategies needed to prevent the establishment, and potentially reverse, latent infection.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- signaling pathway
- heart rate
- heart rate variability
- lps induced
- oxidative stress
- liver injury
- south africa
- liver fibrosis
- nuclear factor
- drug induced
- blood pressure
- immune response