TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors.

Canrong LiYuguo YiYingyi OuyangFengzhi ChenChuxin LuShujun PengYifan WangXinyu ChenXiao YanHaolun XuShuiming LiLin FengXiaoduo Xie

Published in: Cell & bioscience (2024)

TORSEL is a unique living cell sensor that efficiently detects the inhibition of mTORC1 activity, and histone deacetylase inhibitors such as panobinostat target mTORC1 signaling through amino acid sensing.

Keyphrases

histone deacetylase
amino acid
single cell
cell therapy
drug delivery