GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization.
E Scott HalsteadTodd M UmsteadMichael L DaviesYuka Imamura KawasawaPatricia SilveyraJudie HowyrlakLinlin YangWeichao GuoSanmei HuEranda Kurundu HewageZissis C ChroneosPublished in: Respiratory research (2018)
Our data indicate that application of high levels of GM-CSF in the lung after influenza A virus infection alters pathogenic "M1-like" macrophage inflammation. These results indicate a possible therapeutic strategy for respiratory virus-associated pneumonia and acute lung injury.
Keyphrases
- lipopolysaccharide induced
- oxidative stress
- dendritic cells
- lps induced
- electronic health record
- adipose tissue
- cell proliferation
- cardiovascular events
- transcription factor
- big data
- endothelial cells
- risk factors
- inflammatory response
- mouse model
- peripheral blood
- type diabetes
- cardiovascular disease
- machine learning
- artificial intelligence
- respiratory tract
- coronary artery disease
- respiratory failure
- community acquired pneumonia