Pathophysiology of tumour-induced microangiopathic haemolytic anaemia.
Pavani ChalasaniJennifer M SegarMarilyn MarronAlison StopeckPublished in: BMJ case reports (2016)
Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombs-negative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CA-MAHA.
Keyphrases
- metastatic breast cancer
- case report
- end stage renal disease
- newly diagnosed
- iron deficiency
- chronic kidney disease
- induced apoptosis
- ejection fraction
- prognostic factors
- peritoneal dialysis
- high glucose
- cell cycle arrest
- cardiovascular events
- oxidative stress
- diabetic rats
- cardiovascular disease
- signaling pathway
- locally advanced
- cell death
- cell proliferation
- patient reported outcomes