Mucosal pathogenesis in gastro-esophageal reflux disease.
Ahsen UstaogluAnh NguyenStuart SpechlerDaniel SifrimRhonda SouzaPhilip WoodlandPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
The purpose of this review is to consider the crosstalk of different factors of the esophageal mucosa in the pathogenesis of GERD, with a particular focus on mucosal innervation and molecular basis of acid-induced cytokine response. We discuss the current understanding of the mucosal response to acid injury, the nociceptive role of acid-sensitive receptors expressed in the esophageal mucosa, and the role of esophageal epithelial cells in initiating the onset of erosive esophagitis.
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