Characterization of a xenograft model for anti-CD19 CAR T cell studies.
N AhmadbeigiS AlatabM VaseiA RanjbarS AghayanA KhorsandK MoradzadehZ DarvishyanM JamaliSamad MuhammadnejadPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2021)
We demonstrate that the Raji cell line inoculation route could determine the xenograft model system behavior in terms of survival, tumor burden, and dissemination pattern and gives the model the specific features suitable for testing the specific hypothesis in CAR T cell therapy. We also conclude outcome measures for CAR T cell studies that do not require imaging techniques.