Understanding the effect of spatial positioning of coated blade spray devices relative to the mass spectrometry inlet on different instrument platforms and its application to quantitative analysis of fentanyl and related analogs.

We demonstrated that optimization of MS parameters on different instrument vendors and front ends, such as the position of the CBS tip regarding the MS inlet, is vital to exploit the full quantitative potential of this technology. Application of the technology to screen and quantify fentanyl and analogues showed great potential when considering its coupling with portable mass spectrometers for therapeutic drug monitoring and point-of-care applications.