No developmental toxicity observed with dolutegravir in rat whole embryo culture.

Lorraine M PosobiecSharon P ChapmanStacia F MurzynJoyce E RendemontiDinesh J StanislausElizabeth H Romach

Published in: Birth defects research (2021)

DTG at the maximum human recommended dose administered to rats in a whole embryo culture assay did not produce any abnormal effects, while the positive control Valproic Acid produced abnormal effects, including neural tube defects.

Keyphrases

endothelial cells
oxidative stress
high throughput
pregnant women