Exploring causality with biliary atresia at different levels: two-sample Mendelian randomization study.

Shaowen LiuJiayinaxi MushaZhiru WangXueting WangTengfei LiJianghua Zhan

Published in: World journal of pediatric surgery (2024)

In this study, eotaxin, G-CSF, MCP-1/MCAF, and X-12261 levels were shown to be risk factors for BA. However, CD8dim NKT/T cells ratio, CD8dim NKT counts, and CD8dim NKT/lymphocyte ratio were protective factors for BA. These findings provided a promising genetic basis for the etiology, diagnosis, and treatment of BA.

Keyphrases

gene expression
emergency department
genome wide
nk cells
dna methylation
copy number
adverse drug