Pouchitis Is Associated with Paneth Cell Dysfunction and Ameliorated by Exogenous Lysosome in a Rat Model Undergoing Ileal Pouch Anal Anastomosis.

Yi XuZeqian YuJianfeng GongTenghui ZhangFeng ZhuJianfeng Gong

Published in: Microorganisms (2023)

Paneth cell dysfunction is prominent in patients and rat models of pouchitis and may be one of its causes. The decrease in Lachnospiraceae, a characteristic of dysbiosis in pouchitis, could be reserved by lysosome treatment. Lysozyme supplementation shows promise as a novel treatment strategy for pouchitis.

Keyphrases

oxidative stress
single cell
end stage renal disease
cell therapy
newly diagnosed
stem cells
prognostic factors
combination therapy
high grade
artificial intelligence
single molecule