Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer.
James T TophamChris J O'CallaghanHarriet FeilotterHagen F KenneckeYoung S LeeWeimin LiKimberly C BanksKatie QuinnDaniel J RenoufDerek J JonkerDongsheng TuEric X ChenJonathan M LoreePublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
Paired tissue and ctDNA sequencing identified multiple novel mutations, copy gains, and fusions associated with anti-EGFR therapy that frequently co-occur as subclonal alterations in the same patient.