Cognitive and functional progression of dementia in two longitudinal studies.
Yuwei WangMiriam L HaaksmaInez H G B RamakersFrans R J VerheyWiesje M van de FlierPhilip ScheltensIngrid van MaurikMarcel G M Olde RikkertJeannie-Marie S LeoutsakosRené Johannes Franciscus MelisPublished in: International journal of geriatric psychiatry (2019)
Trajectories of slow and rapid dementia progression were identified in both samples. Despite using the same statistical methods, the number of latent trajectories was not replicated and the relative class sizes differed considerably across datasets. These results call for careful consideration when comparing progression estimates in the literature. In addition, the observed discrepancy between cognitive and functional decline stresses the need to monitor dementia progression across multiple domains.