Proteomic identification of biomarkers in maternal plasma that predict the outcome of rescue cerclage for cervical insufficiency.

Kisoon DanJi Eun LeeDohyun HanSun Min KimSubeen HongHyeon Ji KimKyo Hoon Park

Published in: PloS one (2021)

Proteomic analysis identified useful and independent plasma biomarkers (IGFBP-2, PSG4, and LXN; verified by MRM) that predict poor pregnancy outcome following rescue cerclage. Their combined analysis in a multi-biomarker panel significantly improved predictability.

Keyphrases

preterm birth
pregnancy outcomes
gestational age
birth weight
physical activity
body mass index
weight loss