A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice.

Shweta VarshneyHua-Xing WeiFrank BatistaMohd NaumanSubha SundaramKatherine SiminovitchAnkit TanwarPamela Stanley

Published in: BMC developmental biology (2019)

We conclude that the 129S2/SvPasCrl genome contains a dominant modifying gene that rescues the functions of NOTCH1[12f] in signaling. Identification of the modifying gene has the potential to illuminate novel factor(s) that promote Notch signaling when an O-fucose glycan is absent from EGF12 of NOTCH1.

Keyphrases

genome wide
cell proliferation
copy number
dna methylation
mouse model
high fat diet induced
metabolic syndrome
insulin resistance
bioinformatics analysis
genome wide analysis