Tregs dysfunction aggravates postoperative cognitive impairment in aged mice.
Yile ZhouHuihui JuYan HuTingting LiZhouyi ChenYuan SiXia SunYi ShiHao FangPublished in: Journal of neuroinflammation (2023)
Blocking peripheral regulatory T cells improves surgery-induced cognitive function in aged mice. Therefore, aged Tregs play an essential role in the occurrence of POCD.
Keyphrases
- regulatory t cells
- cognitive impairment
- high fat diet induced
- dendritic cells
- minimally invasive
- oxidative stress
- risk assessment
- patients undergoing
- coronary artery bypass
- diabetic rats
- drug induced
- wild type
- adipose tissue
- metabolic syndrome
- immune response
- percutaneous coronary intervention
- atrial fibrillation
- stress induced
- chemotherapy induced