Mitochondrial metabolism related markers GDF-15, FGF-21, and HIF-1α are elevated in pediatric migraine attacks.

Yasemin Baranoglu KilincErkan KilincAysegul DanisFatma HanciSevim TurayAynur OzgeHayrunnisa Bolay Belen

Published in: Headache (2023)

Migraine attacks are accompanied by elevated HIF-1α, FGF-21, GDF-15, CGRP, and PACAP-38 in medication-naive pediatric patients with migraine. Elevated circulating mitochondrial metabolism/ROS-related peptides suggest a mitochondrial stress in pediatric migraine attacks and may have potential diagnostic value in monitoring disease progression and treatment response in children. Novel approaches intervening with mitochondrial metabolism need to be investigated.

Keyphrases

oxidative stress
healthcare
young adults
dna damage
endothelial cells
cell death
reactive oxygen species
climate change
mass spectrometry
adverse drug
atomic force microscopy
heat stress
amino acid
drug induced