Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin.

Daniela ŠimčíkováDominik GardášKateřina HložkováMartin HrudaPetr ŽáčekLukáš RobPetr Heneberg

Published in: Cancer & metabolism (2021)

We provided the evidence that HK1 is involved in the so far unknown glycolysis-independent HK1-metformin axis and influences metabolism even in glucose-free conditions.

Keyphrases

high dose
high glucose
low dose
stem cell transplantation
blood glucose
induced apoptosis
oxidative stress
metabolic syndrome
signaling pathway
skeletal muscle
glycemic control