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Interaction between intravenous thrombolysis and clinical outcome between slow and fast progressors undergoing mechanical thrombectomy: a post-hoc analysis of the SWIFT-DIRECT trial.

Gaultier MarnatJohannes KaesmacherLukas BuetikoferIgor SibonSuzana SalemeRaoul PopHilde HenonPatrik MichelMichael MazighiZsolt KulcsarKevin JanotPaolo MachiAleksandra PikulaJean-Christophe GentricMaria Hernández-PérezLars Udo KrauseGuillaume TurcDavid S LiebeskindJan GrallaUrs Fischernull null
Published in: Journal of neurointerventional surgery (2023)
In this SWIFT-DIRECT subanalysis, we did not find evidence for a significant interaction of the velocity of infarct growth on the odds of favourable outcome according to treatment by MT alone or combined IVT+MT. However, prior IVT was associated with significantly reduced occurrence of any ICH among slow progressors whereas this was increased in fast progressors.
Keyphrases
  • pulmonary embolism
  • risk assessment
  • clinical trial
  • high dose
  • phase iii
  • acute ischemic stroke
  • acute myocardial infarction
  • blood flow
  • coronary artery disease
  • low dose
  • open label