Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells.
Sweelin ChewRiikka LampinenLiudmila SavelevaPaula KorhonenNikita MikhailovAlexandra GrubmanJose M PoloTrevor WilsonMika KomppulaTeemu RönkköCheng GuAlan Mackay-SimTarja MalmAnthony R WhitePasi JalavaKatja M KanninenPublished in: Particle and fibre toxicology (2020)
Key mitochondrial functions were perturbed by urban PM exposure in a physiologically relevant cellular model via a mechanism involving NPTX1. In addition, inflammatory response and early signs of apoptosis accompanied mitochondrial dysfunction during exposure to PM. Findings from this study contribute to increased understanding of harmful PM effects on human health and may provide information to support mitigation strategies targeted at air pollution.
Keyphrases
- particulate matter
- air pollution
- human health
- cell cycle arrest
- inflammatory response
- climate change
- risk assessment
- oxidative stress
- induced apoptosis
- lung function
- cell death
- endothelial cells
- endoplasmic reticulum stress
- pi k akt
- cancer therapy
- signaling pathway
- health information
- induced pluripotent stem cells
- toll like receptor
- cell proliferation
- social media
- immune response