Calcineurin inhibitors in steroid and anti-TNF-alpha refractory immune checkpoint inhibitor colitis.
Eva ZhangChristopher John KielyNeomal SandanayakeStephen TattersallPublished in: JGH open : an open access journal of gastroenterology and hepatology (2021)
The calcineurin inhibitors cyclosporine and tacrolimus appear to be a safe and effective option for the management of patients with infliximab-refractory ICI colitis. The therapeutic benefit is observed rapidly, and adverse effects appear to be limited with close monitoring.
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