Biocompatible polyvinyl alcohol nanofibers loaded with amoxicillin and salicylic acid to prevent wound infections.
Ayca AydinSongul UlagAli ŞahinBurak AksuOguzhan GunduzCem Bulent UstundagIoana Cristina MarinasMihaela GeorgescuMariana Carmen ChifiriucPublished in: Biomedical materials (Bristol, England) (2023)
Diabetic wounds are one of the most challenging clinical conditions in diabetes, necessitating the development of new treatments to foster healing and prevent microbial contamination. In this study, polyvinyl alcohol (PVA) was used as a matrix polymer, and amoxicillin (AMX) and salicylic acid (SA) were selected as bioactive compounds with antimicrobial (with AMX) and anti-inflammatory action (with SA) to obtain innovative drug-loaded electrospun nanofiber patches for the management of diabetic wounds. The scanning electron microscopy (SEM) images showed uniform and beadless structures of the nanofiber patches. The mechanical test results showed that AMX slightly increased the tensile strength, whereas SA significantly decreased the tensile strength value. The obtained patches showed efficient antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) strains. The excellent biocompatibility maintained up to 7 days of contact with the fibroblast cells supports the potential of the obtained patches to fabricate novel wound dressings.
Keyphrases
- wound healing
- gram negative
- electron microscopy
- staphylococcus aureus
- escherichia coli
- multidrug resistant
- anti inflammatory
- induced apoptosis
- type diabetes
- high resolution
- biofilm formation
- cell cycle arrest
- risk assessment
- human health
- microbial community
- klebsiella pneumoniae
- deep learning
- emergency department
- ionic liquid
- convolutional neural network
- methicillin resistant staphylococcus aureus
- cancer therapy
- metabolic syndrome
- skeletal muscle
- oxidative stress
- mass spectrometry
- cell proliferation
- endoplasmic reticulum stress
- signaling pathway
- climate change