SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF.

Kai FengQing ShiDongyue JiaoYingji ChenWanqi YangKe SuYalan WangYan HuangPingzhao ZhangYao LiChenji Wang

Published in: Cell & bioscience (2022)

Our findings provide new insights into the molecular link between SPOP mutation-driven tumorigenesis and aberrant BRAF-dependent activation of the MAPK/ERK pathway.

Keyphrases

metastatic colorectal cancer
signaling pathway
wild type
pi k akt
oxidative stress
cell proliferation
single molecule