Agomelatine potentiates anti-nociceptive effects of morphine in a mice model for diabetic neuropathy: involvement of NMDA receptor subtype NR1 within the raphe nucleus and periaqueductal grey.

Sibel Ozcan Ozgur Bulmus Nazife Ulker Sinan Canpolat Ebru Onalan Etem Sinem Oruç Ahmet Yardimci Funda Gülcü Bulmus Ahmet Ayar Haluk Kelestimur Mete Özcan

Published in: Neurological research (2020)

Ca2+: Calcium; D2DR: Dopamine D2 receptor; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; GluN1: Glutamate ionotropic receptor N-methyl-D-aspartate type subunit-1; 5-HT: 5-hydroxytryptamine; i.p.: intraperitoneal injection; MPE: Maximal possible effect; MT: Melatonin; NMDA: N-methyl-D-aspartate; NMDAR1: NMDA receptors-1; PAG: Periaqueductal grey; PKCγ: Protein kinase C gamma; RT-PCR: Real time polymerase chain reaction; STZ: Streptozotocin.

Keyphrases

protein kinase
diabetic rats
white matter
type diabetes
high fat diet
resistance training
neuropathic pain
heart rate
binding protein
high fat diet induced
multiple sclerosis
spinal cord
wild type