The effect of carriers' reproductive choices and pregnancy history on sporadic severe haemophilia: A 20-year retrospective study through a regional registry.

Federica Riccardi Antonio Coppola Gianna Franca Rivolta Annalisa Matichecchia Gabriele QuintavalleChiara BiasoliLelia ValdrèLydia PiscitelliAntonio Percesepe Annarita Tagliaferri

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2022)

In this cohort sporadic offspring account for more than 70% of severe haemophilia cases. This increasing proportion is likely to reflect the influence in reproductive choices of awareness of carriers' status, particularly in sporadic mothers, and of prenatal diagnosis options.

Keyphrases

late onset
early onset
amyotrophic lateral sclerosis
high fat diet
preterm birth
adipose tissue
drug induced
metabolic syndrome
insulin resistance