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Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism.

Ryan LuskLaura M SabaLauren A VanderlindenVaclav ZidekJan SilhavyMichal PravenecPaula L HoffmanBoris Tabakoff
Published in: Alcoholism, clinical and experimental research (2018)
We propose that our analytical pipeline can successfully identify genetic regions and transcripts which predispose a particular phenotype and our analysis provides functional context for coexpression module components.
Keyphrases
  • genome wide
  • machine learning
  • copy number