PSC is rarely seen in clinical practice and commonly occurs in elder men with smoking history. Tumor tissue PD-L1 expression ≥1% and MET abnormalities may predict inferior prognosis of PSC and lymph node metastasis was determined as the independent prognosticator of PSC. Surgical resection along with adjuvant medical treatment is the cornerstone for early and locally advanced patients, and the clinical utility of molecular targeting therapy and immunotherapy in PSC needs to be further investigated.
Keyphrases
- lymph node metastasis
- squamous cell carcinoma
- locally advanced
- clinical practice
- end stage renal disease
- ejection fraction
- newly diagnosed
- healthcare
- chronic kidney disease
- early stage
- rectal cancer
- neoadjuvant chemotherapy
- papillary thyroid
- clinical trial
- prognostic factors
- stem cells
- smoking cessation
- tyrosine kinase
- drug delivery
- mesenchymal stem cells
- mass spectrometry
- atomic force microscopy
- single molecule
- high resolution
- cell therapy
- replacement therapy