Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates.

Michael Wallisch Christina U Lorentz Hari Hara Sudhan LakshmananJennifer JohnsonMarschelle R CarrisCristina PuyDavid Gailani Monica T Hinds Owen J T McCarty András GruberErik I Tucker

Published in: Research and practice in thrombosis and haemostasis (2020)

FXII represents a possible therapeutic and safe target for reducing platelet deposition and fibrin formation during medical interventions including extracorporeal membrane oxygenation.

Keyphrases

extracorporeal membrane oxygenation
acute respiratory distress syndrome
respiratory failure
healthcare
physical activity
mechanical ventilation
contrast enhanced
magnetic resonance imaging
intensive care unit
computed tomography
magnetic resonance