Engineered reproductive tissues.

Emma S GargusHunter B RogersKelly E McKinnonMaxwell E EdmondsTeresa K Woodruff

Published in: Nature biomedical engineering (2020)

Engineered male and female biomimetic reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell and embryo function, and to display characteristic endocrine phenotypic patterns, such as the 28-day human ovulatory cycle. In this Review, we summarize how engineered reproductive tissues facilitate research in reproductive biology, and overview strategies for making engineered reproductive tissues that might eventually allow the restoration of reproductive capacity in patients.

Keyphrases

gene expression
end stage renal disease
germ cell
newly diagnosed
ejection fraction
peritoneal dialysis
pregnant women
induced pluripotent stem cells
pregnancy outcomes
patient reported