Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation.
Se-Eun LeeJung-Hoon KimChiyeon LimSuin ChoPublished in: Chinese medicine (2020)
Mice administered RAGE before the tMCAO operation had less neuronal cell death than those that were not administered RAGE prior to the operation, and this study provides preclinical evidence for use of A. gigas in ischemic stroke.
Keyphrases
- brain injury
- cerebral ischemia
- signaling pathway
- subarachnoid hemorrhage
- cell death
- mouse model
- pi k akt
- blood brain barrier
- oxidative stress
- atrial fibrillation
- epithelial mesenchymal transition
- cell cycle arrest
- high fat diet induced
- metabolic syndrome
- stem cells
- induced apoptosis
- bone marrow
- cell proliferation
- insulin resistance
- endoplasmic reticulum stress